Now, more than ever, we are focused on sharing inventions – from medical research to devices to software – that have the potential to impact the COVID-19 crisis.
All of these technologies are currently available for license.
Diagnostics, Therapeutics, and Potential Vaccine Applications for COVID-19
Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals (UA21-195)
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2, which is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent with high enzymatic inhibition and antiviral activity against SARS-CoV-2.
PLpro Inhibitors Against SARS-CoV-2 (UA21-133)
This technology introduces novel, highly-potent papain-like protease (PLpro) inhibitory compounds that can be used to stop the viral replication of COVID-19. This can be used retroactively to slow the spread of the disease in individuals who have already become infected with COVID-19. PLpro inhibitors have also been shown to be useful antivirals for other human coronaviruses, giving this technology potential to be used to develop treatments for future infectious diseases that resemble COVID-19.
Discovery of Non-Covalent Inhibitors Targeting the SARS-CoV-2 Main Protease (UA21-099)
This technology is the development of novel inhibitors for the main protease of SARS-CoV-2. These inhibitors are notable, as they are non-covalent with high enzymatic inhibition and antiviral activity against SARS-CoV-2.
Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) with a Polypeptide (UA20-216)
This technology is an effective treatment for coronavirus symptoms. It administers a polypeptide through a pharmaceutically acceptable salt form to counteract the harmful effects of Angiotensin-II in patients infected with a SARS coronavirus.
Repurposing of a Known Drug for Treatment of the Novel Coronavirus SARS-CoV-2 (COVID-19) (UA21-020)
This invention uses an existing drug to promote antiviral activity to treat COVID-19.
Serological Assays for SARS-CoV-2 (UA20-226)
This invention is a serological assay to test for prior exposure to SARS-CoV-2. The technology uses a two-step protocol to maximize the specificity of the assay and reduce false positives.
Bioreactive Compounds for Use in Inhibiting SARS-CoV-2 Replication (UA20-172)
This invention is the discovery of inhibitors targeting the SARS-CoV-2 main protease. These inhibitors have potential for use as therapeutics against COVID-19 as well as other SARS and MERS strains.
Rapid Image-Based Screening for Bioactive Compounds that Block SARS-CoV-2 Replication Cycle (UA20-225)
This invention is a rapid image-based drug screening software platform for bioactive compounds that can block SARS-CoV-2 replication cycles.
Detection of Virus through Particle Counting on Paper Microfluidics Using Smartphone-Based Fluorescence Microscope (UA20-057)
This invention uses a smartphone-based fluorescence microscope and an image-processing algorithm to detect norovirus, and could be used to detect COVID-19.
A Designer Probiotic-Based Intervention to Prevent Infection (UA15-131)
This technology is a Lactobacillus system that serves as a vaccine platform with the potential to develop COVID-19 therapeutics.
A Safe, Tolerable, Non-Antibiotic Agent to Prevent or Treat Infection (UA18-039)
This invention is an advancement of a Lactobacillus system that represents a vaccine platform to express surface antigens to mitigate infection. This has potential for COVID-19 therapeutics.
Ultra-High Sensitivity RT-PCR for Viral Genome Sequencing (UA16-197)
This invention is a novel process for reconstructing genome sequences of RDA-DNA fragments, such as would be present in archived or damaged biological samples. This has potential application for COVID-19 and other viral/infectious disease screening, clinical diagnostics, and vaccine research.
Respiratory Technologies for COVID-19
Natural Treatment for Ventilation Induced Lung Injury (UA16-075)
This invention is the use of a NRF2 inducer to reduce the lung damage caused by mechanical ventilation. This can be used to treat ventilator-related lung damage in patients with COVID-19.
Imaging Human Respiratory Gas Patterns, Volume, Rate and Carbon Dioxide (UA20-239)
This invention is a multi-camera-based system that can produce 3D images of human respiratory gas patterns, volume, rate, and carbon dioxide (CO2) content through two complementary imaging techniques. It has the ability to safely monitor COVID-19 patients for acute respiratory distress syndrome (ARDS) before major complications can arise.
Covid-19 Time of Intubation Mortality Evaluation (C-TIME) (UA22-015)
This invention describes software that uses a scoring system for calculating the probable mortality of patients with COVID-19 pneumonia at the time they require mechanical ventilation.
Potential Testing Applications for COVID-19
Handheld, Rapid, Extremely Sensitive Assay of SARS-CoV-2 Infections (UA21-090)
This invention is a rapid antigen test to detect the presence of SARS-CoV-2 that uses fluorescent immunoassay technology using a smartphone-based fluorescent microscope.
Detection of H1N1 Influenza A Using Wire-Guide Droplet Manipulations (UA11-031)
This technology is a reprogrammable wire-guided droplet microfluidics tool that is simple enough to be fabricated into a handheld device for use in field situations. The entire analysis can be finished in less than 15 minutes including serial dilution, centrifuging, DNA extraction, thermocycling and real-time quantification. This has potential for use in COVID-19 testing applications.
Interfacial Effects Enable Droplet Actuation, Inhibition Relief, and Early Sensing of Polymerase Chain Reaction (UA15-071)
This technology is a device and associated methods that improve quantitative real-time polymerase chain reaction (qPCR) by allowing detection of PCR amplification and quantification of initial target amount to occur at an earlier amplification cycle. This innovation is possible through the novel utilization of interfacial effects in PCR reaction droplets. Ultimately this allows for faster results and faster informed medical decision-making in the point-of-care setting and has potential for COVID-19 testing application.
Public Health Technologies for COVID-19
eHIP - the eHealth & Intervention Platform (UA16-123)
This invention is a platform for conducting mobile device-based health interventions and behavioral research. This can be used to collect information about the spread of COVID-19 in communities. Pima County in Arizona is using this technology for its AZCOVIDTXT program.
DASH-SAFE: A Multi-Modal GIS-Based Real-Time COVID Risk Assessment, Management, & Navigation Tool (UA21-048)
This invention is a COVID risk assessment tool for university campuses that provides real time feedback, maps out potential areas of risk, and provides users potential routes around those areas on university campuses. Furthermore, the dashboard would provide information for individuals to assess their own risk.
We Health Covid Watch Arizona (UA21-047)
This invention is an app that uses a multi-variable analysis of distance between others, volume of exposure, and likelihood of COVID-19 infection to give the user a personalized recommendation for self-quarantine. The app is available for download at WeHealth Arizona.
Optical Tools for COVID-19 Biomedical Research
Integrated Frequency-Locked Optical Whispering Evanescent Resonator (FLOWER) Bio-sensor (UA19-084)
This invention is a card-sized mini-computer that acts as a data processing center able to measure low concentrations of biological and chemical molecules down to the single-molecule limit. This optical technology has remote sensing capabilities that can be used in biomedical research for COVID-19.
Label-Free Single Molecule Spectroscopy and Detection (UA18-063)
This invention incorporates FLOWER (a label-free biological and chemical sensing system) with dual frequency comb spectroscopy for molecular detection as well as identification. Inventors have improved the signal to noise ratio of these measurements more than 1000 times using frequency locking feedback control in combination with innovative data processing techniques. This optical technology has remote sensing capabilities that can be used in biomedical research for COVID-19.
Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes for Label-Free and Ultrasensitive Detection (UA19-073)
This invention is a new surface smoothing method for microtoroid optical resonators, resulting in ultrasensitive detection and reduced scattering loss when looking for key biomarkers in medical imaging. This has potential application in biomarker detection for patients with COVID-19, as well as vaccine research.
Alternative Disinfectants for Preventing Spread
Natural Plant-Based Hand Sanitizer (UA20-229)
This invention is a combination of plant-derived extracts formulated to mitigate bacterial and viral pathogens that can be used as a natural hand sanitizer.
Software for Modeling Infectious Disease Outbreaks
Predictive Modeling of People Movement and Disease Spread on Campus under COVID and Pandemic Situations (UA21-051)
This invention provides university policy makers a novel simulation based on a student-mobility model (a GIS map overlaid with daily student schedules including classrooms, buildings, dorms, etc.) in tandem with a disease propagation model (showing student health, shedding rate of the disease, number of infected students in various locations, probabilities of disease transmissions, etc.) so administrators can get insight into the impact of policy decisions.
Epidemic Predictive Model (EpiGro) (UA16-052)
This technology is a software that models and predicts epidemic case counts. This software is complete with an easy-to-use graphical user interface (GUI), and can be used to monitor COVID-19.